Summary: The researchers discovered 69 genetic variants associated with tempo synchrony, or the ability to move in synchrony with the tempo of music.
source: Vanderbilt University
The first large-scale genomic study of music – published on today’s cover The nature of human behavior -Identified 69 genetic variants associated with tempo synchrony, which means the ability to move in synchrony with the tempo of music.
An international team of scientists, including the Vanderbilt Genetics Institute and 23andMe, have shown that the human ability to move in sync with a musical rhythm (termed… Synchronization beat) partially in the human genome.
Several genes associated with beat synchronization are involved in central nervous system function, including genes expressed very early in brain development and in areas underlying auditory and motor skills, according to co-lead author Rena Gordon, PhD, associate professor in the department of otolaryngology. Larynx – Head and Neck Surgery and Co-Director of the Vanderbilt Laboratory of Musical Perception.
“Rhythm is affected not just by one gene, but by hundreds of genes,” Gordon said. “Tapping, clapping and dancing in sync with the beat of the music is the essence of our human music.”
The study also discovered that beat synchrony shares some of its genetic structure with other traits, including circadian rhythms such as walking and breathing and circadian patterns.
Co-lead author Leah Davis said:And the Assistant Professor of Medicine.
23andMe’s Big Research Dataset provided study data from more than 600,000 customers who agreed to participate in the research, allowing researchers to identify genetic alleles that differed by participants’ impulse synchronization ability.
“The large number of approved study participants provided a unique opportunity for our group to pick up even small genetic cues,” said David Hinds, PhD, a research fellow and statistical geneticist at 23andMe.
“These findings represent a leap forward in the scientific understanding of the links between genetics and music.”
First author Maria Niarchu, PhD, assistant professor in the Department of Medicine, said the study findings “create new links between genetic and neural engineering of musical rhythm, thereby improving our understanding of how our genomes tune our brains to the rhythm of music.” Music.”
Financing: The work was supported in part by NIH Director New Innovator Award #DP2HD098859.
About this genetic research news
author: Craig Boerner
source: Vanderbilt University
Contact: Craig Burner – Vanderbilt University
picture: The image is in the public domain
original search: open access.
“A genome-wide association study of musical rhythm synchronization demonstrates polygenicityWritten by Rina Gordon et al. The nature of human behavior
A genome-wide association study of musical rhythm synchronization demonstrates polygenicity
Moving in sync with the beat is an essential component of music. Here we performed a genome-wide association study to identify common genetic variants associated with hit synchrony in 606,825 individuals.
The orchestration of the hits showed a highly polygenic structure, with 69 loci reaching genome-wide significance (s<5 x 10−8) and single-nucleotide-based heritability (on the scale of responsibility) from 13% to 16%.
The heritability of genes expressed in brain tissue and regulatory elements of fetal and adult genes was enriched, confirming the role of CNS-expressed genes associated with the genetic basis of the trait.
We performed self-report phenotypic validations (by separate experiments) and a genome-wide association study (polygenic scores of rhythm synchronization were associated with patients algorithmically classified as musicians in the medical records of a separate biobank).
Genetic associations with respiratory function, motor function, processing speed and temporal pattern suggest a common genetic architecture with beat synchrony and provide avenues for novel phenotypic and epigenetic explorations.